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Many patients report significant pain reduction within weeks, often experiencing continued improvement as new tissue develops

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Additionally, we sought to demonstrate specificity of RSL3 for targeting BRAF/RAS addicted cancer cells by selecting TPC-1, a PTC cell line, that lacks RAS or BRAF mutations

The review also covered three therapeutic research strategies: direct GSH depletion (leading to ferroptosis or enhanced chemotherapy sensitivity), indirect approaches targeting the tumour microenvironment, and prodrug strategies utilising elevated tumour GSH for drug activation